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Article

Guanine nucleotide pool imbalance impairs multiple steps of protein synthesis and disrupts GCN4 translational control in Saccharomyces cerevisiae.

Genetics - 1 Jan 2011

Iglesias-Gato Diego, Martín-Marcos Pilar, Santos María A, Hinnebusch Alan G, Tamame Mercedes

Abstract excerpt

Purine nucleotides are structural components of the genetic material, function as phosphate donors, participate in cellular signaling, are cofactors in enzymatic reactions, and constitute the main carriers of cellular energy. Thus, imbalances in A/G nucleotide biosynthesis affect nearly the whole...

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Identifiers

PMID: 20980241
DOI: 10.1534/genetics.110.122135
PMCID: PMC3018310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20980241-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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