Article
Primary cilia regulate Shh activity in the control of molar tooth number.
Development (Cambridge, England) - 1 Mar 2009
Ohazama Atsushi, Haycraft Courtney J, Seppala Maisa, Blackburn James, Ghafoor Sarah, Cobourne Martyn, Martinelli David C, Fan Chen-Ming, Peterkova Renata, Lesot Herve, Yoder Bradley K, Sharpe Paul T
Abstract excerpt
Primary cilia mediate Hh signalling and mutations in their protein components affect Hh activity. We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, Shh activity is increased in the toothless diastema mesenchyme of the embryonic jaw primordia. This results in the formation of ectopic teeth in the diastema, mesial to the first molars. This phenotype is specific to loss...
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