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Article

PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals.

Developmental biology - 15 Mar 2010

Zeng Huiqing, Hoover Amber N, Liu Aimin

Abstract excerpt

The PCP effector gene Inturned regulates planar cell polarity (PCP) and wing hair formation in Drosophila wings. In order to understand the roles for Inturned in mammalian embryonic development, we generated a null mutant allele for the mouse homologue of Inturned (Intu) via gene-targeting in ES cells. Mouse Intu null mutants are homozygous lethal at midgestation, exhibiting multiple defects including neural tube...

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Identifiers

PMID: 20067783
DOI: 10.1016/j.ydbio.2010.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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