Article
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2008
Breunig Joshua J, Sarkisian Matthew R, Arellano Jon I, Morozov Yury M, Ayoub Albert E, Sojitra Sonal, Wang Baolin, Flavell Richard A, Rakic Pasko, Town Terrence
Abstract excerpt
Primary cilia are present on mammalian neurons and glia, but their function is largely unknown. We generated conditional homozygous mutant mice for a gene we termed Stumpy. Mutants lack cilia and have conspicuous abnormalities in postnatally developing brain regions, including a hypoplasic hippocampus characterized by a primary deficiency in neural stem cells known as astrocyte-like neural precursors (ALNPs)....
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