Article
Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2021
Hruba Eva, Kavkova Michaela, Dalecka Linda, Macholan Miloš, Zikmund Tomas, Varecha Miroslav, Bosakova Michaela, Kaiser Jozef, Krejci Pavel, Hovorakova Maria, Buchtova Marcela
Abstract excerpt
The Sprouty family is a highly conserved group of intracellular modulators of receptor tyrosine kinase (RTK)-signaling pathways, which have been recently linked to primary cilia. Disruptions in the structure and function of primary cilia cause inherited disorders called ciliopathies. We aimed to evaluate Sprouty2 and Sprouty4 gene-dependent alterations of ciliary structure and to focus on the determination of its...
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