Intraflagellar transport is essential for endochondral bone formation.

doi:10.1242/dev.02732

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Article

Intraflagellar transport is essential for endochondral bone formation.

Development (Cambridge, England) - 1 Jan 2007

Haycraft Courtney J, Zhang Qihong, Song Buer, Jackson Walker S, Detloff Peter J, Serra Rosa, Yoder Bradley K

Abstract excerpt

While cilia are present on most cells in the mammalian body, their functional importance has only recently been discovered. Cilia formation requires intraflagellar transport (IFT), and mutations disrupting the IFT process result in loss of cilia and mid-gestation lethality with developmental defects that include polydactyly and abnormal neural tube patterning. The early lethality in IFT mutants has hindered...

Topics

Animals
Body Patterning
Bone Development
Carrier Proteins
Cilia
Female
Flagella
Gene Expression Regulation, Developmental
Hedgehog Proteins
In Situ Hybridization
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Mice, Mutant Strains

Mice, Transgenic

Mutation

Phenotype

Polydactyly

Source

Open in PubMed

Identifiers

PMID: 17166921
DOI: 10.1242/dev.02732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17166921-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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