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Article

Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.

Developmental biology - 1 Jan 2016

Gazea Mary, Tasouri Evangelia, Tolve Marianna, Bosch Viktoria, Kabanova Anna, Gojak Christian, Kurtulmus Bahtiyar, Novikov Orna, Spatz Joachim, Pereira Gislene, Hübner Wolfgang, Brodski Claude, Tucker Kerry L, Blaess Sandra

Abstract excerpt

Midbrain dopaminergic (mDA) neurons modulate various motor and cognitive functions, and their dysfunction or degeneration has been implicated in several psychiatric diseases. Both Sonic Hedgehog (Shh) and Wnt signaling pathways have been shown to be essential for normal development of mDA neurons. Primary cilia are critical for the development of a number of structures in the brain by serving as a hub for...

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PMID: 26542012
DOI: 10.1016/j.ydbio.2015.10.033
PMCID: PMC5873949

Genes

IFT88

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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