Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains.

doi:10.1084/jem.174.4.799

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains.

The Journal of experimental medicine - 1 Oct 1991

Sant A J, Hendrix L R, Coligan J E, Maloy W L, Germain R N

Abstract excerpt

Distinct combinations of class II major histocompatibility complex (MHC) alpha and beta chains show widely varying efficiencies of cell surface expression in transfected cells. Previous studies have analyzed the regions of the class II chains that are critically involved in this phenomenon of variable expression and have shown a predominant effect of the NH2-terminal domains comprising the peptide-binding site....

Topics

Alleles
Amino Acid Sequence
Animals
Antibodies, Monoclonal
Cell Membrane
Gene Expression Regulation
Genes, MHC Class II
Golgi Apparatus
Histocompatibility Antigens Class II
L Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leucine

Macromolecular Substances

Mice

Molecular Sequence Data

Peptides

Protein Processing, Post-Translational

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1919435
DOI: 10.1084/jem.174.4.799
PMCID: PMC2118973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1919435-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains.PMID 1919435Read ↗

Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression.Semantic proximity Read ↗

The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo.Semantic proximity Read ↗

Intracellular transport of class I MHC molecules in antigen processing mutant cell lines.Semantic proximity Read ↗

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.Semantic proximity Read ↗

Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain.Semantic proximity Read ↗

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.Semantic proximity Read ↗

MHC class II-restricted presentation of intracellular antigen.Semantic proximity Read ↗

Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences.Semantic proximity Read ↗

Association of the Invariant Chain with Major Histocompatibility Complex Class I Molecules Directs Trafficking to Endocytic CompartmentsSemantic proximity Read ↗

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.Semantic proximity Read ↗

Defective presentation of endogenous antigen by a cell line expressing class I molecules.Semantic proximity Read ↗

Expression of I-A alpha k and allelic restriction on A alpha/A beta pairing in transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.