Article
Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences.
European journal of immunology - 1 Feb 1999
Ulbrecht M, Couturier A, Martinozzi S, Pla M, Srivastava R, Peterson P A, Weiss E H
Abstract excerpt
The formation of a trimeric complex composed of MHC class I heavy chain, beta2-microglobulin (beta2m) and peptide ligand is a prerequisite for its efficient transport to the cell surface. We have previously demonstrated impaired intracellular transport of the human class Ib molecule HLA-E in mouse myeloma X63 cells cotransfected with the genes for HLA-E and human beta2m (hbeta2m), which is most likely...
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