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Article

MHC class II-restricted presentation of intracellular antigen.

Cell - 22 Feb 1991

Weiss S, Bogen B

Abstract excerpt

An endogenously produced immunoglobulin light chain (lambda 2(315] is processed and presented to T cells in association with major histocompatibility complex (MHC) class II molecules. Using transfectants producing variant forms of lambda 2(315) that are neither expressed on the cell surface nor secreted, we demonstrate that intracellular lambda 2(315), which has never been exported outside of the cell, is the...

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Source

Identifiers

PMID: 1847667
DOI: 10.1016/0092-8674(91)90506-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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MHC class II-restricted presentation of intracellular antigen.PMID 1847667Read ↗

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Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.Semantic proximity Read ↗

Class I MHC molecules: assembly and antigen presentation.Semantic proximity Read ↗

MHC class II-associated invariant chain contains a sorting signal for endosomal compartmentsSemantic proximity Read ↗

Natural T-cell ligands that are created by genetic variants can be transferred between cells by extracellular vesicles.Semantic proximity Read ↗

Defective presentation of endogenous antigen by a cell line expressing class I molecules.Semantic proximity Read ↗

Naturally-occurring peptide antigens derived from the MHC class-I-restricted processing pathway.Semantic proximity Read ↗

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.Semantic proximity Read ↗

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.Semantic proximity Read ↗

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