Article
Variance components linkage analysis with repeated measurements.
Human heredity - 1 Jan 2009
Liang Liming, Chen Wei-Min, Sham Pak C, Abecasis Gonçalo R
Abstract excerpt
BACKGROUND: When subjects are measured multiple times, linkage analysis needs to appropriately model these repeated measures. A number of methods have been proposed to model repeated measures in linkage analysis. Here, we focus on assessing the impact of repeated measures on the power and cost of a linkage study. METHODS: We describe three alternative extensions of the variance components approach to accommodate...
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