Article
Joint tests of linkage and association for quantitative traits.
Theoretical population biology - 1 Nov 2001
Allison D B, Neale M C
Abstract excerpt
In this paper we describe various study designs and analytic techniques for testing the joint hypothesis that a genetic marker is both linked to and associated with a quantitative phenotype. Issues of power and sampling are addressed. The distinction between methods that explicitly examine association and those that infer association by examining the distribution of allelic transmissions from a heterozygous...
Topics
- Alleles
- Chromosome Mapping
- Family
- Genetic Markers
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Quantitative Trait, Heritable