Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Robust LOD scores for variance component-based linkage analysis.

Genetic epidemiology - 1 Jan 2000

Blangero J, Williams J T, Almasy L

Abstract excerpt

The variance component method is now widely used for linkage analysis of quantitative traits. Although this approach offers many advantages, the importance of the underlying assumption of multivariate normality of the trait distribution within pedigrees has not been studied extensively. Simulation studies have shown that traits with leptokurtic distributions yield linkage test statistics that exhibit excessive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Genetic Linkage
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lod Score

Share to Models, Genetic

Share to Probability

Share to Quantitative Trait, Heritable

Source

Identifiers

PMID: 11055364
DOI: 10.1002/1098-2272(2000)19:1+<::AID-GEPI2>3.0.CO;2-Y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Robust LOD scores for variance component-based linkage analysis.PMID 11055364Read ↗

Variance component methods for detecting complex trait loci.Semantic proximity Read ↗

Estimating the power of variance component linkage analysis in large pedigrees.Semantic proximity Read ↗

Variance components linkage analysis with repeated measurements.Semantic proximity Read ↗

Genetic linkage studies.Semantic proximity Read ↗

Robust variance-components approach for assessing genetic linkage in pedigrees.Semantic proximity Read ↗

Smoothing of the bivariate LOD score for non-normal quantitative traits.Semantic proximity Read ↗

Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure.Semantic proximity Read ↗

A two-stage approximation for analysis of mixture genetic models in large pedigrees.Semantic proximity Read ↗

Power of variance component linkage analysis to detect epistasis.Semantic proximity Read ↗

Bayesian mapping of quantitative trait loci under the identity-by-descent-based variance component model.Semantic proximity Read ↗

A fast linkage method for population GWAS cohorts with related individuals.Semantic proximity Read ↗

Least squares estimation of variance components for linkage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.