Article
Overview of linkage analysis in complex traits.
Current protocols in human genetics - 1 Jan 2010
Bush William S, Haines Jonathan
Abstract excerpt
Linkage analysis is a well-established and powerful method for mapping disease genes. While linkage analysis has been most successful when applied to disorders with clear patterns of Mendelian inheritance, it can also be a useful technique for mapping susceptibility genes for common complex diseases. In this unit, we outline the key concepts of complex disease, and how linkage analysis for complex traits differs...
Topics
- Follow-Up Studies
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Techniques
- Genome-Wide Association Study
- Humans
- Pneumonia, Aspiration