Article
Linkage analysis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Barrett Jennifer H, Teare M Dawn
Abstract excerpt
Linkage analysis is used to map genetic loci using observations on relatives. It can be applied to both major gene disorders (parametric linkage) and complex diseases (model-free or non-parametric linkage), and it can be based on either a relatively small number of microsatellite markers or a denser map of single nucleotide polymorphisms (SNPs). We describe the methods commonly used to map loci influencing...
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