Genetic linkage studies.

doi:10.1016/S0140-6736(05)67382-5

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Article

Genetic linkage studies.

Lancet (London, England) - 1 Jan 2000

Dawn Teare M, Barrett Jennifer H

Abstract excerpt

Linkage analysis is used to map genetic loci by use of observations of related individuals. We provide an introduction to methods commonly used to map loci that predispose to disease. Linkage analysis methods can be applied to both major gene disorders (parametric linkage) and complex diseases (model-free or non-parametric linkage). Evidence for linkage is most commonly expressed as a logarithm of the odds score....

Topics

Chromosome Mapping
Ehlers-Danlos Syndrome
Genetic Heterogeneity
Genetic Linkage
Lod Score
Phenotype
Statistics, Nonparametric

Source

Open in PubMed

Identifiers

PMID: 16168786
DOI: 10.1016/S0140-6736(05)67382-5

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