Article
A fast linkage method for population GWAS cohorts with related individuals.
Genetic epidemiology - 1 Apr 2023
Zajac Gregory J M, Gagliano Taliun Sarah A, Sidore Carlo, Graham Sarah E, Åsvold Bjørn O, Brumpton Ben, Nielsen Jonas B, Zhou Wei, Gabrielsen Maiken, Skogholt Anne H, Fritsche Lars G, Schlessinger David, Cucca Francesco, Hveem Kristian, Willer Cristen J, Abecasis Gonçalo R
Abstract excerpt
Linkage analysis, a class of methods for detecting co-segregation of genomic segments and traits in families, was used to map disease-causing genes for decades before genotyping arrays and dense SNP genotyping enabled genome-wide association studies in population samples. Population samples often contain related individuals, but the segregation of alleles within families is rarely used because traditional linkage...
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