Article
Re-transformation of non-transformed hybrids between c-myc-activating mouse plasmacytoma cells and normal fibroblasts by transfection with activated c-Ha-ras but not c-myc.
International journal of cancer - 30 Sept 1991
Satoh C, Oikawa T, Kondoh N, Kuzumaki N
Abstract excerpt
In a mouse plasmacytoma S194, c-myc oncogene is rearranged with Ig gene by chromosomal translocation and is consequently activated. We previously reported that transformation of phenotype and expression of rearranged c-myc were repressed in independently isolated hybrid clones, I-1 and IV-10, between S194 and normal fibroblasts. In order to investigate the relationship between transformation of phenotype and...
Topics
- Animals
- Cell Line, Transformed
- Fibroblasts
- Gene Expression Regulation
- Genes, myc
- Genes, ras
- Hybrid Cells
- Mice
- Phenotype
- Plasmacytoma
- Transfection