Article
Role of c-Myc on erythroid differentiation.
The Tohoku journal of experimental medicine - 1 Oct 1992
Ohmori Y, Tanabe J, Terashima M, Shoji W, Takada S, Obinata M
Abstract excerpt
In the early event of the induction of mouse erythroleukemia (MEL) cell differentiation, c-myc mRNA levels show a biphasic change. The elevated expression of a transfected c-myc gene inhibits the commitment and differentiation of MEL cell transformants. In the present work, we have introduced human c-myc mutants into MEL cells under the inducible promoter to define the functional domains of c-Myc involved in...
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