Immune response to progressor variants derived from transfection of an ultraviolet radiation-induced C3H mouse regressor tumor cell line with activated Harvey-ras oncogene.

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Article

Immune response to progressor variants derived from transfection of an ultraviolet radiation-induced C3H mouse regressor tumor cell line with activated Harvey-ras oncogene.

Cancer research - 1 Jun 1990

Kaba D S, Pierceall W E, Price J E, Ananthaswamy H N

Abstract excerpt

Skin cancers induced in mice by UV radiation often exhibit a regressor phenotype. In order to determine how tumors escape the immune defenses of the normal immunocompetent host, we sought to isolate progressor variants from a UV radiation-induced C3H mouse regressor fibrosarcoma cell line, UV-2240, by transfection with an activated Ha-ras oncogene. A cotransfection protocol using pSV2-neo DNA, which confers...

Topics

Animals
Antigens, Neoplasm
Cell Line
Cross Reactions
DNA, Neoplasm
Female
Fibrosarcoma
Genes, ras
Histocompatibility Antigens
Humans
Immune Tolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung Neoplasms

Mice

Mice, Inbred C3H

Mice, Nude

Neoplasms, Radiation-Induced

Phenotype

Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 2185882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2185882-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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