Increased cell-substrate adhesion accompanies conditional reversion to the normal phenotype in ras-oncogene-transformed NIH-3T3 cells.

doi:10.1006/excr.1994.1280

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Article

Increased cell-substrate adhesion accompanies conditional reversion to the normal phenotype in ras-oncogene-transformed NIH-3T3 cells.

Experimental cell research - 1 Oct 1994

Shumaker D K, Sklar M D, Prochownik E V, Varani J

Abstract excerpt

We recently reported (1991, Mol. Cell Biol. 11, 3699-3710) that depletion of c-myc protein by myc antisense sequences in ras-transformed NIH-3T3 cells reverses several of the malignant characteristics of these cells. These include transformed morphology, growth in soft agar, and ability to form t...

Topics

3T3 Cells
Animals
Cell Adhesion
Cell Transformation, Neoplastic
Fibronectins
Fluorescent Antibody Technique
Genes, myc
Genes, ras
Mice
Phenotype
Proto-Oncogene Proteins p21(ras)
RNA, Antisense
Trypsin

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