Article
Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts.
Oncogene - 30 Jul 1998
Fedele M, Berlingieri M T, Scala S, Chiariotti L, Viglietto G, Rippel V, Bullerdiek J, Santoro M, Fusco A
Abstract excerpt
Overexpression of the high mobility group I (HMGI) proteins is often associated with the malignant phenotype. Moreover, many benign human tumors, mainly of mesenchymal origin, are characterized by rearrangements of the HMGI-C gene. In most cases, HMGI-C alterations involve breaks within the third intron of the gene resulting in aberrant transcripts carrying exons from 1-3, which encode the three DNA binding...
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