Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts.

doi:10.1038/sj.onc.1201952

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Article

Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts.

Oncogene - 30 Jul 1998

Fedele M, Berlingieri M T, Scala S, Chiariotti L, Viglietto G, Rippel V, Bullerdiek J, Santoro M, Fusco A

Abstract excerpt

Overexpression of the high mobility group I (HMGI) proteins is often associated with the malignant phenotype. Moreover, many benign human tumors, mainly of mesenchymal origin, are characterized by rearrangements of the HMGI-C gene. In most cases, HMGI-C alterations involve breaks within the third...

Topics

3T3 Cells
Animals
Cell Division
Cell Transformation, Neoplastic
High Mobility Group Proteins
Mice
Mutagenesis
Phenotype
Recombinant Fusion Proteins
Transfection

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