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Article

An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen.

Protein science : a publication of the Protein Society - 1 Feb 2009

Janowiak Blythe E, Finkelstein Alan, Collier R John

Abstract excerpt

Heptameric pores formed by the protective antigen (PA) moiety of anthrax toxin translocate the intracellular effector moieties of the toxin across the endosomal membrane to the cytosol of mammalian cells. We devised a protocol to characterize the effects of individual mutations in a single subunit of heptameric PA prepores (pore precursors) or pores. We prepared monomeric PA containing a test mutation plus an...

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Identifiers

PMID: 19165720
DOI: 10.1002/pro.35
PMCID: PMC2708049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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