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Article

Identification of new dominant-negative mutants of anthrax protective antigen using directed evolution.

Applied biochemistry and biotechnology - 1 Nov 2012

Wu Gaobing, Feng Chunfang, Cao Sha, Guo Aizhen, Liu Ziduo

Abstract excerpt

The anthrax toxin is composed of three proteins: protective antigen (PA), lethal factor (LF), and edema toxin (EF). The PA moiety carries EF and LF into the cytosol of mammalian cells via a mechanism that depends on the oligomerization of PA and transmembrane pore formation by the PA oligomer. Certain mutants of PA, termed dominant-negative (DN) mutants, can co-oligomerize with wild-type PA and disrupt the...

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Identifiers

PMID: 22948605
DOI: 10.1007/s12010-012-9858-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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