Article
Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax.
Science (New York, N.Y.) - 27 Apr 2001
Sellman B R, Mourez M, Collier R J
Abstract excerpt
The protective antigen moiety of anthrax toxin translocates the toxin's enzymic moieties to the cytosol of mammalian cells by a mechanism that depends on its ability to heptamerize and insert into membranes. We identified dominant-negative mutants of protective antigen that co-assemble with the wild-type protein and block its ability to translocate the enzymic moieties across membranes. These mutants strongly...
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