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Article

Membrane insertion by anthrax protective antigen in cultured cells.

Molecular and cellular biology - 1 Jul 2005

Qa'dan Maen, Christensen Kenneth A, Zhang Lei, Roberts Thomas M, Collier R John

Abstract excerpt

The enzymatic moieties of anthrax toxin enter the cytosol of mammalian cells via a pore in the endosomal membrane formed by the protective antigen (PA) moiety. Pore formation involves an acidic pH-induced conformational rearrangement of a heptameric precursor (the prepore), in which the seven 2beta2-2beta3 loops interact to generate a 14-strand transmembrane beta-barrel. To investigate this model in vivo, we...

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Identifiers

PMID: 15964805
DOI: 10.1128/MCB.25.13.5492-5498.2005
PMCID: PMC1156972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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