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Article

Selection and evaluation of the immunogenicity of protective antigen mutants as anthrax vaccine candidates.

Vaccine - 13 Feb 2008

Yan Ming, Roehrl Michael H, Basar Emre, Wang Julia Y

Abstract excerpt

Protective antigen (PA) is a central component of anthrax toxin and a major antigen in anthrax vaccines. However, the use of native PA as a vaccine is not optimal. If administered to people who have been freshly exposed to anthrax, PA may actually aid in anthrax toxin formation and thus may pose a serious safety concern for postexposure vaccination applications. A non-functional PA mutant may be a much safer...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18192092
DOI: 10.1016/j.vaccine.2007.11.087
PMCID: PMC2254513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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