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Article

Characterization of dominant-negative forms of anthrax protective antigen.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2000

Yan Ming, Collier R John

Abstract excerpt

Certain mutations within the protective antigen (PA) moiety of anthrax toxin endow the protein with a dominant-negative (DN) phenotype, converting it into a potent antitoxin. Proteolytically activated PA oligomerizes to form ring-shaped heptameric complexes that insert into the membrane of an aci...

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PMID: 12765339
PMCID: PMC1430378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12765339-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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