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Article

Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors.

The Journal of biological chemistry - 29 Mar 2013

Phillips Damilola D, Fattah Rasem J, Crown Devorah, Zhang Yi, Liu Shihui, Moayeri Mahtab, Fischer Elizabeth R, Hansen Bryan T, Ghirlando Rodolfo, Nestorovich Ekaterina M, Wein Alexander N, Simons Lacy, Leppla Stephen H, Leysath Clinton E

Abstract excerpt

Anthrax toxin protective antigen (PA) delivers its effector proteins into the host cell cytosol through formation of an oligomeric pore, which can assume heptameric or octameric states. By screening a highly directed library of PA mutants, we identified variants that complement each other to exclusively form octamers. These PA variants were individually nontoxic and demonstrated toxicity only when combined with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23393143
DOI: 10.1074/jbc.M113.452110
PMCID: PMC3610978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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