Article
A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2006
Melnyk Roman A, Collier R John
Abstract excerpt
Heptameric pores formed in the endosomal membrane by the protective antigen moiety of anthrax toxin serve as portals for entry of the enzymatic moieties of the toxin into the cytosol. In the aqueous lumen of each pore is a "Phe clamp," a heptad of narrowly apposed Phe residues (Phe-427), that catalyzes the unfolding and translocation of the enzymatic moieties across the membrane. Here, we provide evidence for a...
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