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Article

Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008

Sun Jianjun, Lang Alexander E, Aktories Klaus, Collier R John

Abstract excerpt

The protective antigen (PA) moiety of anthrax toxin forms a heptameric pore in endosomal membranes of mammalian cells and translocates the enzymatic moieties of the toxin to the cytosol of these cells. Phenylalanine-427 (F427), a solvent-exposed residue in the lumen of the pore, was identified earlier as being crucial for the transport function of PA. The seven F427 residues were shown in electrophysiological...

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Identifiers

PMID: 18334631
DOI: 10.1073/pnas.0800701105
PMCID: PMC2393744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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