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Article

Structure of the Anthrax Protective Antigen D425A Dominant Negative Mutant Reveals a Stalled Intermediate State of Pore Maturation.

Journal of molecular biology - 15 May 2022

Scott Harry, Huang Wei, Andra Kiran, Mamillapalli Sireesha, Gonti Srinivas, Day Alexander, Zhang Kaiming, Mehzabeen Nurjahan, Battaile Kevin P, Raju Anjali, Lovell Scott, Bann James G, Taylor Derek J

Abstract excerpt

The tripartite protein complex produced by anthrax bacteria (Bacillus anthracis) is a member of the AB family of β-barrel pore-forming toxins. The protective antigen (PA) component forms an oligomeric prepore that assembles on the host cell surface and serves as a scaffold for binding of lethal and edema factors. Following endocytosis, the acidic environment of the late endosome triggers a pH-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35304125
DOI: 10.1016/j.jmb.2022.167548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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