Article
PBX1 is dispensable for neural commitment of RA-treated murine ES cells.
In vitro cellular & developmental biology. Animal - 1 Jan 2000
Jürgens Anne S, Kolanczyk Mateusz, Moebest Dietrich C C, Zemojtel Tomasz, Lichtenauer Urs, Duchniewicz Marlena, Gantert Melanie P, Hecht Jochen, Hattenhorst Uwe, Burdach Stefan, Dorn Annette, Kamps Mark P, Beuschlein Felix, Räpple Daniel, Scheele Jürgen S
Abstract excerpt
Experimentation with PBX1 knockout mice has shown that PBX1 is necessary for early embryogenesis. Despite broad insight into PBX1 function, little is known about the underlying target gene regulation. Utilizing the Cre-loxP system, we targeted a functionally important part of the homeodomain of PBX1 through homozygous deletion of exon-6 and flanking intronic regions leading to exon 7 skipping in embryonic stem...
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