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Article

A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells.

Molecular cell - 18 Nov 2021

Jaensch Elizabeth S, Zhu Jinjin, Cochrane Jesse C, Marr Sharon K, Oei Theresa A, Damle Manashree, McCaslin Ethan Z, Kingston Robert E

Abstract excerpt

The CBX family of proteins is central to proper mammalian development via key roles in Polycomb-mediated maintenance of repression. CBX proteins in differentiated lineages have chromatin compaction and phase separation activities that might contribute to maintaining repressed chromatin. The predominant CBX protein in pluripotent cells, CBX7, lacks the domain required for these activities. We inserted this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34637753
DOI: 10.1016/j.molcel.2021.09.018
PMCID: PMC8966356

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