Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.

Genes & development - 15 Jan 2008

Hori Kei, Cholewa-Waclaw Justyna, Nakada Yuji, Glasgow Stacey M, Masui Toshihiko, Henke R Michael, Wildner Hendrik, Martarelli Benedetta, Beres Thomas M, Epstein Jonathan A, Magnuson Mark A, Macdonald Raymond J, Birchmeier Carmen, Johnson Jane E

Abstract excerpt

Neural networks are balanced by inhibitory and excitatory neuronal activity. The formation of these networks is initially generated through neuronal subtype specification controlled by transcription factors. The basic helix-loop-helix (bHLH) transcription factor Ptf1a is essential for the generation of GABAergic inhibitory neurons in the dorsal spinal cord, cerebellum, and retina. The transcription factor Rbpj is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cerebellum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chick Embryo

Share to gamma-Aminobutyric Acid

Share to Immunoglobulin J Recombination Signal Sequence-Binding Protein

Share to Neurons

Share to Receptors, Notch

Share to Spinal Cord

Source

Open in PubMed Open full text

Identifiers

PMID: 18198335
DOI: 10.1101/gad.1628008
PMCID: PMC2192752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.PMID 18198335Read ↗

Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum.Semantic proximity Read ↗

Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons.Semantic proximity Read ↗

Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn.Semantic proximity Read ↗

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.Semantic proximity Read ↗

A network of genetic repression and derepression specifies projection fates in the developing neocortex.Semantic proximity Read ↗

<i>Ptf1a</i> robustly drives the gliogenic switch in the rodent embryonic cortex in a dosage-dependent manner by activating pro-glial gene expression programsSemantic proximity Read ↗

Ptf1a/Rbpj complex inhibits ganglion cell fate and drives the specification of all horizontal cell subtypes in the chick retinaSemantic proximity Read ↗

Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons.Semantic proximity Read ↗

Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons.Semantic proximity Read ↗

The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.Semantic proximity Read ↗

Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP.Semantic proximity Read ↗

Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.