Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.

Developmental biology - 15 Sept 2008

Capellini Terence D, Zewdu Rediet, Di Giacomo Giuseppina, Asciutti Stefania, Kugler Jamie E, Di Gregorio Anna, Selleri Licia

Abstract excerpt

The post-cranial axial skeleton consists of a metameric series of vertebral bodies and intervertebral discs, as well as adjoining ribs and sternum. Patterning of individual vertebrae and distinct regions of the vertebral column is accomplished by Polycomb and Hox proteins in the paraxial mesoderm, while their subsequent morphogenesis depends partially on Pax1/Pax9 in the sclerotome. In this study, we uncover that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Bromodeoxyuridine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Dosage

Share to In Situ Hybridization

Share to Paired Box Transcription Factors

Share to PAX9 Transcription Factor

Share to Polycomb-Group Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18691704
DOI: 10.1016/j.ydbio.2008.04.005
PMCID: PMC5918304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.PMID 18691704Read ↗

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.Semantic proximity Read ↗

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.Semantic proximity Read ↗

Pax1 and Pax9 synergistically regulate vertebral column development.Semantic proximity Read ↗

Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis.Semantic proximity Read ↗

The role of Pax-1 in axial skeleton development.Semantic proximity Read ↗

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice.Semantic proximity Read ↗

Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.Semantic proximity Read ↗

Positional cloning of a global regulator of anterior-posterior patterning in mice.Semantic proximity Read ↗

In vivo genome-wide analysis of multiple tissues identifies gene regulatory networks, novel functions and downstream regulatory genes for Bapx1 and its co-regulation with Sox9 in the mammalian vertebral column.Semantic proximity Read ↗

The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development.Semantic proximity Read ↗

Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.Semantic proximity Read ↗

Juxtaposed Polycomb complexes co-regulate vertebral identity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.