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Article

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Development (Cambridge, England) - 1 Jun 2014

Gilmour Jane, Assi Salam A, Jaegle Ulrike, Kulu Divine, van de Werken Harmen, Clarke Deborah, Westhead David R, Philipsen Sjaak, Bonifer Constanze

Abstract excerpt

Mammalian development is regulated by the interplay of tissue-specific and ubiquitously expressed transcription factors, such as Sp1. Sp1 knockout mice die in utero with multiple phenotypic aberrations, but the underlying molecular mechanism of this differentiation failure has been elusive. Here, we have used conditional knockout mice as well as the differentiation of mouse ES cells as a model with which to...

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Identifiers

PMID: 24850855
DOI: 10.1242/dev.106054
PMCID: PMC4050696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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