Article
A gene expression profile of embryonic stem cells and embryonic stem cell-derived neurons.
Restorative neurology and neuroscience - 1 Jan 2001
Loring J F, Porter J G, Seilhammer J, Kaser M R, Wesselschmidt R
Abstract excerpt
Embryonic stem (ES) cells have the ability to differentiate into a variety of cell lineages. We are examining ES cell differentiation in vitro by using cDNA microarrays to generate a molecular phenotype for each cell type. El4 ES cells induced by retinoic acid after forming embryoid bodies differentiate almost exclusively to neurons. We obtained expression patterns for about 8500 gene sequences by comparing mRNAs...
Topics
- Cell Differentiation
- Cells, Cultured
- Fetus
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Humans
- Neurons
- Oligonucleotide Array Sequence Analysis
- Phenotype
- Stem Cells