Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cells.

Cell death and differentiation - 1 Jun 2007

Manabe T, Tatsumi K, Inoue M, Makinodan M, Yamauchi T, Makinodan E, Yokoyama S, Sakumura R, Wanaka A

Abstract excerpt

L3/Lhx8 is a member of the LIM-homeobox gene family. Previously, we demonstrated that L3/Lhx8-null mice specifically lacked cholinergic neurons in the basal forebrain. In the present study, we conditionally suppressed L3/Lhx8 function during retinoic acid-induced neural differentiation of a murine embryonic stem (ES) cell line using an L3/Lhx8-targeted small interfering RNA (siRNA) produced by an H1.2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Choline O-Acetyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to In Situ Nick-End Labeling

Share to LIM-Homeodomain Proteins

Share to Oligodendroglia

Share to Prosencephalon

Share to RNA, Small Interfering

Source

Identifiers

PMID: 17318222
DOI: 10.1038/sj.cdd.4402106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cells.PMID 17318222Read ↗

Knockdown of the L3/Lhx8 gene suppresses cholinergic differentiation of murine embryonic stem cell-derived spheres.Semantic proximity Read ↗

The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons.Semantic proximity Read ↗

Identifying regulators of neural stem cell fate and tumourigenesisSemantic proximity Read ↗

Expression and possible functions of the cholinergic system in a murine embryonic stem cell lineSemantic proximity Read ↗

Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversificationSemantic proximity Read ↗

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.Semantic proximity Read ↗

The Controlled Generation of Functional Basal Forebrain Cholinergic Neurons from Human Embryonic Stem CellsSemantic proximity Read ↗

Expression of Tlx in both stem cells and transit amplifying progenitors regulates stem cell activation and differentiation in the neonatal lateral subependymal zone.Semantic proximity Read ↗

Efficient Differentiation of Mouse Embryonic Stem Cells into Motor NeuronsSemantic proximity Read ↗

Defective neuronogenesis in the absence of Dlx5.Semantic proximity Read ↗

Origin and molecular specification of striatal interneurons.Semantic proximity Read ↗

Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.