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Article

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition.

The Journal of experimental medicine - 16 Jan 2009

Archbold Julia K, Macdonald Whitney A, Gras Stephanie, Ely Lauren K, Miles John J, Bell Melissa J, Brennan Rebekah M, Beddoe Travis, Wilce Matthew C J, Clements Craig S, Purcell Anthony W, McCluskey James, Burrows Scott R, Rossjohn Jamie

Abstract excerpt

Human leukocyte antigen (HLA) gene polymorphism plays a critical role in protective immunity, disease susceptibility, autoimmunity, and drug hypersensitivity, yet the basis of how HLA polymorphism influences T cell receptor (TCR) recognition is unclear. We examined how a natural micropolymorphism in HLA-B44, an important and large HLA allelic family, affected antigen recognition. T cell-mediated immunity to an...

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Share to Complementarity Determining Regions
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19139173
DOI: 10.1084/jem.20082136
PMCID: PMC2626662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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