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HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

2 Nov 2018

Abstract excerpt

Immunophenotypic differences between closely related human leukocyte antigen (HLA) alleles have been associated with divergent clinical outcomes in infection, autoimmunity, transplantation and drug hypersensitivity. Here we explore the impact of micropolymorphism on peptide antigen presentation by three closely related HLA molecules, HLA-B*57:01, HLA-B*57:03 and HLA-B*58:01, that are differentially associated...

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PMID: 30410026
DOI: 10.1038/s41467-018-07109-w

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