Article
A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition.
The Journal of experimental medicine - 1 Sept 2003
Macdonald Whitney A, Purcell Anthony W, Mifsud Nicole A, Ely Lauren K, Williams David S, Chang Linus, Gorman Jeffrey J, Clements Craig S, Kjer-Nielsen Lars, Koelle David M, Burrows Scott R, Tait Brian D, Holdsworth Rhonda, Brooks Andrew G, Lovrecz George O, Lu Louis, Rossjohn Jamie, McCluskey James
Abstract excerpt
HLA-B*4402 and B*4403 are naturally occurring MHC class I alleles that are both found at a high frequency in all human populations, and yet they only differ by one residue on the alpha2 helix (B*4402 Asp156-->B*4403 Leu156). CTLs discriminate between HLA-B*4402 and B*4403, and these allotypes stimulate strong mutual allogeneic responses reflecting their known barrier to hemopoeitic stem cell transplantation....
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