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Article

The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family.

Haematologica - 1 Jan 2011

Bade-Döding Christina, Theodossis Alex, Gras Stephanie, Kjer-Nielsen Lars, Eiz-Vesper Britta, Seltsam Axel, Huyton Trevor, Rossjohn Jamie, McCluskey James, Blasczyk Rainer

Abstract excerpt

BACKGROUND: Polymorphic differences between human leukocyte antigen (HLA) molecules affect the specificity and conformation of their bound peptides and lead to differential selection of the T-cell repertoire. Mismatching during allogeneic transplantation can, therefore, lead to immunological reactions. DESIGN AND METHODS: We investigated the structure-function relationships of six members of the HLA-B*41 allelic...

Topics

Epitopes, T-Lymphocyte
HLA-B Antigens
Humans
Peptide Fragments
Polymorphism, Single Nucleotide
Protein Binding
Protein Conformation
Recombinant Proteins
Spectrometry, Mass, Electrospray Ionization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 20934997
DOI: 10.3324/haematol.2010.030924
PMCID: PMC3012774

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