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Article

A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism.

The Journal of biological chemistry - 13 Jun 2014

Liu Yu Chih, Chen Zhenjun, Neller Michelle A, Miles John J, Purcell Anthony W, McCluskey James, Burrows Scott R, Rossjohn Jamie, Gras Stephanie

Abstract excerpt

Mutations within T cell epitopes represent a common mechanism of viral escape from the host protective immune response. The diverse T cell repertoire and the extensive human leukocyte antigen (HLA) polymorphism across populations is the evolutionary response to viral mutation. However, the molecular basis underpinning the interplay between HLA polymorphism, the T cell repertoire, and viral escape is unclear. Here...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24759101
DOI: 10.1074/jbc.M114.563502
PMCID: PMC4059114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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