Article
Uncommon P1 Anchor-featured Viral T Cell Epitope Preference within HLA-A*2601 and HLA-A*0101 Individuals.
ImmunoHorizons - 1 Jun 2024
Zhang Jianing, Yue Can, Lin Yin, Tian Jinmin, Guo Yuanyuan, Zhang Danni, Guo Yaxin, Ye Beiwei, Chai Yan, Qi Jianxun, Zhao Yingze, Gao George F, Sun Zeyu, Liu Jun
Abstract excerpt
The individual HLA-related susceptibility to emerging viral diseases such as COVID-19 underscores the importance of understanding how HLA polymorphism influences peptide presentation and T cell recognition. Similar to HLA-A*0101, which is one of the earliest identified HLA alleles among the human population, HLA-A*2601 possesses a similar characteristic for the binding peptide and acts as a prevalent allomorph in...
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