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Article

Functional polymorphism of the glucocorticoid receptor gene associates with mania and hypomania in bipolar disorder.

Bipolar disorders - 1 Feb 2009

Spijker Anne T, van Rossum Elisabeth F C, Hoencamp Erik, DeRijk Roel H, Haffmans Judith, Blom Marc, Manenschijn Laura, Koper Jan W, Lamberts Steven Wj, Zitman Frans G

Abstract excerpt

OBJECTIVES: In affective disorders, dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis is a frequently observed phenomenon. Subtle changes in glucocorticoid receptor (GR) functioning caused by polymorphisms of the GR gene (NR3C1) may be at the base of the altered reaction of the HPA axis to stress and subsequently related to the development and course of affective disorders. The aim of our study is to...

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Identifiers

PMID: 19133972
DOI: 10.1111/j.1399-5618.2008.00647.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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