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Article

Glucocorticoid Receptor Polymorphisms in Major Depression

1 Oct 2009

Abstract excerpt

Previously, it has been suggested that hypothalamic-pituitary-adrenal (HPA) axis dysregulation and, as a consequence, increased cortisol levels, is not only a state phenomenon, but may also be a trait phenomenon in mood disorders. Cortisol exerts its effects mainly by binding to the glucocorticoid receptor (GR) and, of particular interest in certain brain regions, the mineralocorticoid receptor (MR). Several GR...

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PMID: 19906241
DOI: 10.1111/j.1749-6632.2009.04985.x

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