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Article

Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.

Biological psychiatry - 15 Oct 2007

Kumsta Robert, Entringer Sonja, Koper Jan W, van Rossum Elisabeth F C, Hellhammer Dirk H, Wüst Stefan

Abstract excerpt

BACKGROUND: Alterations in glucocorticoid (GC) signaling have been associated with a number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might be one of the factors underlying susceptibility to stress related disease. METHODS: We investigated 206 healthy subjects and assessed associations between four common GR gene (NR3C1) polymorphisms (ER22/23EK, N363S, BclI, 9beta) and...

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PMID: 17716631
DOI: 10.1016/j.biopsych.2007.04.013

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