CYP3A5 *1 allele associated with tacrolimus trough concentrations but not subclinical acute rejection or chronic allograft nephropathy in Japanese renal transplant recipients.

Abstract excerpt

PURPOSE: We assessed reported associations of CYP3A5 *1 allele with a delay in achieving target tacrolimus concentrations, and occurrence of biopsy-confirmed subclinical acute rejection (SAR) and chronic allograft nephropathy (CAN) in Japanese subjects. METHODS: Forty-one renal allograft recipients were studied. The targeted tacrolimus trough concentrations were 20-25 ng/mL up to 2 weeks post-transplantation,...

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