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Article

Dynamic effects of CYP3A5 polymorphism on dose requirement and trough concentration of tacrolimus in renal transplant recipients.

Journal of clinical pharmacy and therapeutics - 1 Feb 2017

Chen P, Li J, Li J, Deng R, Fu Q, Chen J, Huang M, Chen X, Wang C

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Tacrolimus is a widely used immunosuppressive drug with marked pharmacokinetic variability partly due to CYP3A5 polymorphism. Our study aimed to investigate the dynamic effects of CYP3A5 genotypes on dose requirement and trough concentration (C0 ) of tacrolimus in renal transplant recipients. METHODS: A total of 194 Chinese renal transplant recipients received oral tacrolimus twice...

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Share to Cytochrome P-450 CYP3A
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27885697
DOI: 10.1111/jcpt.12480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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